AG-1295(NSC 380341
AG-1295
CAS: 71897-07-9
Molecular Formula: C16H14N2
AG-1295(NSC 380341 - Names and Identifiers
AG-1295(NSC 380341 - Physico-chemical Properties
| Molecular Formula | C16H14N2 |
| Molar Mass | 234.3 |
| Density | 1.127±0.06 g/cm3(Predicted) |
| Melting Point | 121 °C |
| Boling Point | 398.3±37.0 °C(Predicted) |
| Solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| Appearance | White solid |
| Color | Yellow |
| pKa | 1.29±0.30(Predicted) |
| Storage Condition | −20°C |
| In vitro study | AG 1295 inhibits PDGFR autophosphorylation with IC 50 s of 0.3-0.5 μM and 0.5-1 μM for membrane autophosphorylation assays and Swiss 3T3 cells, respectively. AG1295 (10 μM, 100 μM) significantly inhibits rabbit conjunctival fibroblast cell growth stimulated by PDGF-AA or PDGF-BB in vitro. Cell Viability Assay Cell Line: Rabbit conjunctival fibroblasts cells Concentration: 1 μM, 10 μM, 100 μM Incubation Time: 3 days Result: Inhibited rabbit conjunctival fibroblast cell growth stimulated by PDGF-AA or PDGF-BB. |
| In vivo study | AG-1295 reduces neointimal formation in aortic allograft vasculopathy by inhibition of PDGFR-beta-triggered tyrosine phosphorylation. AG1295 (12 mg/kg; i.p.; daily; for 14 or 21 days) significantly reduces interstitial fibrosis as verified by a smaller Sirius-Red stained area and also by a reduced number of macrophages, and by the ED-A+ fibronectin deposition and the number of cells positive for alpha-smooth muscle actin. Animal Model: Sprague-Dawley rats (240-270 g) Dosage: 12 mg/kg Administration: Intraperitoneal injection; daily; for 14 or 21 days Result: Attenuated interstitial fibrosis in rat kidney after unilateral obstruction. |
AG-1295(NSC 380341 - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
AG-1295(NSC 380341 - Introduction
AG-1295 is an organic compound with the chemical name 2-amino -5-(2,6-dimethylphenylamino) phenylpropionic acid. It is a white crystalline solid, practically insoluble in water, but soluble in organic solvents such as dimethyl sulfoxide and chloroform.
AG-1295 is often used as a broad-spectrum antibiotic to prevent and treat some bacterial infections. It has an antibacterial effect and can inhibit the growth and replication of bacteria. In addition, AG-1295 can also be used in biological research, such as to determine the sensitivity and resistance of bacteria to the compound.
The method of preparing AG-1295 is relatively complicated. A common synthetic route is to use aniline as the starting material and synthesize it through multi-step reactions, including substituted aniline, acylation, reduction and so on. Reference is made to the relevant chemical literature for specific synthetic routes and conditions.
With regard to safety information, AG-1295 should follow the relevant safety procedures. Wear appropriate protective equipment, such as safety glasses, gloves and laboratory coats, during use. Avoid inhalation, contact with skin and ingestion to prevent it from entering the eyes and mouth. In case of contact, rinse immediately with plenty of water and seek medical help. Heating or igniting AG-1295 will produce toxic gases, so it needs to be operated in a well-ventilated environment. Keep away from fire and oxidant, and store in a dry and cool place.
AG-1295 is often used as a broad-spectrum antibiotic to prevent and treat some bacterial infections. It has an antibacterial effect and can inhibit the growth and replication of bacteria. In addition, AG-1295 can also be used in biological research, such as to determine the sensitivity and resistance of bacteria to the compound.
The method of preparing AG-1295 is relatively complicated. A common synthetic route is to use aniline as the starting material and synthesize it through multi-step reactions, including substituted aniline, acylation, reduction and so on. Reference is made to the relevant chemical literature for specific synthetic routes and conditions.
With regard to safety information, AG-1295 should follow the relevant safety procedures. Wear appropriate protective equipment, such as safety glasses, gloves and laboratory coats, during use. Avoid inhalation, contact with skin and ingestion to prevent it from entering the eyes and mouth. In case of contact, rinse immediately with plenty of water and seek medical help. Heating or igniting AG-1295 will produce toxic gases, so it needs to be operated in a well-ventilated environment. Keep away from fire and oxidant, and store in a dry and cool place.
Last Update：2024-04-09 20:52:54
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CAS: 71897-07-9
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Product Name: AG-1295 Visit Supplier Webpage Request for quotation
CAS: 71897-07-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 71897-07-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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